PHARMACEUTICAL CHEMISTRY
Pharmaceutical and Medicinal chemistry disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with, search, chemical synthesis ,design and development of pharmaceutical agents (drugs). The Department of Pharmaceutical and Medicinal Chemistry at K. T. PATIL COLLEGE OF PHARMACY, OSMANABAD, have rich history and traditions of academic excellence. More than three hundred graduates have completed the program, and many have leadership positions in academia, government and industry. Our department hosts training programs, seminars and conferences focusing in life and health sciences. Most of our alumni Pharmaceutical Chemist are employed in teaching, research and service activities within universities, medical centres, research institutes, consulting firms, government agencies, pharmaceutical and chemical firms, toxicology laboratories, or other private or public agencies. Our graduate programs incorporate a range of methodologies from molecular to clinical Pharmaceutical Chemistry.
In particular, medicinal chemistry in its most common guise—focusing on small organic molecules—encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities (biological activities and properties), i.e., understanding their structure-activity relationships (SAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products.
At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as Biochemistry, Molecular biology, Pharmacognosy, Pharmacology and toxicology and veterinary and human medicine; these, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in treatment of various diseases.
In discovery of small molecule therapeutics, an emphasis on training that provides for breadth of synthetic experience and "pace" of bench operations is clearly present (e.g., for individuals with pure synthetic organic and natural products synthesis in Ph.D. and post-doctoral positions, ibid.). In the medicinal chemistry specialty areas associated with the design and synthesis of chemical libraries or the execution of process chemistry aimed at viable commercial syntheses (areas generally with fewer opportunities), training paths are often more much more varied (e.g., including focused training in physical organic chemistry, library-related syntheses, etc.).
As such, most entry-level workers in medicinal chemistry do not have formal training in medicinal chemistry but receive the necessary medicinal chemistry and pharmacologic background after employment—at entry into their work in a pharmaceutical company, where the company provides its particular understanding or model of "medichem" training through active involvement in practical synthesis on therapeutic projects. (The same is somewhat true of computational medicinal chemistry specialties, but not to the same degree as in synthetic areas.). Graduate level programs in medicinal chemistry can be found in traditional medicinal chemistry or pharmaceutical sciences departments, both of which are traditionally associated with schools of pharmacy, and in some chemistry departments.
Our Pharmaceutical and Medicinal Chemistry department is well equipped to conduct research in advanced areas, through highly qualified and experienced teachers of good international repute. The department possesses several sophisticated instruments to do frontier research in a broad range of disciplines. These includes UV-VIS, FTIR, NMR and EPR spectrometers, analytical tools like HPLC, GC, Atomic Absorptiometer, Ion and Flash Chromatography units, High Speed Ultra Centrifuge, Electrophoresis Units, Multichannel Analysers, and a host of other instruments. . It will an exciting time for research and education in Pharmaceutical and Medicinal Chemistry department at our College. The Department have long-standing interests and commitments for the education of students.
